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Geriatrics Research
CN: 37-1522/R
ISSN: 2096-9058
Governed by: Health Commission of Shandong Province
Sponsored by: Shandong Provincial Hospital Affiliated to Shandong First Medical University
Editor-in-Chief: SUN Zhijian
Deputy Editor-in-Chief: WANG Jianchun
Founded in 2020, bimonthly.
Indexed by: CNKI, Wanfang, Weipu, Chaoxing, CBM.
Analysis of potentially inappropriate medications in elderly inpatients based on Beers Criteria and Chinese Criteria
WAN Miaomiao;WANG Jianchun;ZHANG Feng;ZHANG Wen;ZHU Xiaojuan;Objective To analyze potentially inappropriate medication(PIM) in elderly inpatients using the 2019 Beers Criteria and the Chinese Criteria of Potentially Inappropriate Medication for Older Adults(2017 edition)(Chinese Criteria). Methods A total of 191 inpatients aged ≥65 years admitted to the Department of Geriatrics of Shandong Provincial Hospital Affiliated to Shandong First Medical University from January to June 2020 were selected. PIM analysis was performed based on the 2019 Beers Criteria and Chinese Criteria. The χ2 test was used to compare the incidence rates of PIM by two criteria across different indicators(age, sex, number of diseases, number of medications, renal function). Results According to the Beers Criteria and Chinese Criteria, the incidence rates of PIM were 72. 25%(138/191) and 60. 73%(116/191), respectively. The most frequent PIM were proton pump inhibitors(based on Beers Criteria) and clopidogrel(based on Chinese Criteria). Difference of PIM incidence was found according to both Beers Criteria and Chinese Criteria among elderly inpatients taking 1-4, 5-9, and ≥10 medications(all P<0. 05). According to the Chinese Criteria, difference in PIM incidence was observed between patients with normal and abnormal renal function(P<0. 05). Conclusions Based on the 2019 Beers Criteria and Chinese Criteria, the incidence of PIM among elderly inpatients is very high. Elderly patients taking more medications and those with abnormal renal function are more prone to PIM.
The predictive value of serum CRP, IL-6 and BNP levelsin elderly patients with chronic heart failure complicated with pulmonary infection
LIU Yalin;WANG Feng;Objective To investigate the predictive value of serum C-reactive protein(CRP), Interleukin-6(IL-6) combined with B-type natriuretic peptide(BNP) in elderly patients with chronic heart failure complicated with pulmonary infection. Methods A total of 112 elderly patients with chronic heart failure admitted to Xi'an People's Hospital(Xi'an Fourth Hospital) from January 2022 to June 2023 were selected and divided into aninfected group(n=46) and an uninfected group(n=66) according to whether they had a concurrent pulmonary infection. The general case data and the number of cases with hypoproteinemia, anemia, abnormal transaminase, renal insufficiency, as well as the levels of CRP, IL-6 and BNP indices of the patients in the two groups were compared with each other. Logistic regression was used to analyze the influencing factors of pulmonary infection in elderly patients with chronic heart failure. The receiver operating characteristic(ROC) curve was plotted to analyze the efficacy of CRP, IL-6 and BNP in predicting pulmonary infection in elderly patients with chronic heart failure. Results The levels of serum CRP(OR=1. 068, 95% CI:1. 011-1. 127, P=0. 018), IL-6(OR=1. 153, 95% CI:1. 032-1. 287, P=0. 012), BNP(OR=1. 007, 95% CI:1. 001-1. 014, P=0. 018) were influencing factors for pulmonary infection in elderly patients with chronic heart failure. The ROC curve analysis showed that the areas under the ROC curve for CRP, IL-6, BNP, and their combination in predicting the occurrence of pulmonary infection in elderly patients with chronic heart failure were 0. 910, 0. 910, 0. 647, and 0. 939 respectively, with sensitivities of 73. 90%, 82. 60%, 50. 00%, and 84. 80% respectively, and specificities of 92. 40%, 87. 90%, 78. 80%, and 93. 90% respectively. Conclusions The levels of serum CRP, IL-6 and BNP are influencing factors for pulmonary infection in elderly patients with chronic heart failure. The combined detection of these three indicators has predictive value for the occurrence of pulmonary infection in elderly patients with chronic heart failure.
Analysis of potential characteristics and influencing factors of anxiety levels in the elderly
ZHANG Yafeng;YANG Shanshan;LI Jia;WANG Chengzeng;FU Hang;Objective To explore the latent classification characteristics of anxiety levels among elderly and identify associated influencing factors. Methods Based on data from the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey(CLHLS), the Generalized Anxiety Disorder-7(GAD-7) scale was used to assess anxiety levels in the elderly, Latent Profile Analysis(LPA) was employed to identify potential categories of anxiety levels, and multivariate logistic regression models were used to examine the factors associated with different anxiety level categories. Results Anxiety levels among elderly were classified into three categories: Q1(low scores on all items, 72. 95%), Q2(moderate scores on all items, 17. 53%), and Q3(high scores on all items, 9. 52%). Multivariate logistic regression analysis indicated that gender, education level, economic status, self-rated health status, depression, and activities of daily living(ADL) were associated with anxiety levels in the elderly(all P<0. 05). Male, higher education, and better economic status were associated with lower anxiety levels(all P<0. 05); whereas poorer self-rated health status, higher levels of depression, and ADL limitations were linked to higher anxiety levels(all P<0. 05). Additionally, the risk of anxiety was slightly higher in the younger elderly compared to the oldest-old, and urban-rural disparities appeared to amplify anxiety severity in the elderly(all P<0. 05). Conclusions Low anxiety levels are predominant among the elderly. The elderly who are female, have lower education and economic status, limited ADL, poorer self-rated health, and depressive tendencies are more prone to anxiety and should be prioritized in screening and intervention efforts.
Analysis of the current status of chronic diseases and multimorbidities among middle-aged and older adults in China based on CHARLS 2020
LIU Tongda;HAO Zhimei;Objective To investigate the current status of chronic non-communicable diseases(referred to as chronic diseases) and multimorbidities among middle-aged and older adults aged 45 years and above in China. Methods Data from the 2020 China Health and Retirement Longitudinal Study(CHARLS) were utilized, including 19 128 middleaged and older adults from 27 provinces. Stata and SPSS software were employed to analyze the prevalence of 15 chronic diseases and multimorbidities. Results In 2020, the prevalence rate of chronic diseases among middle-aged and older adults in China was 80. 9%, and the prevalence rate of multimorbidities was 58. 2%. Statistical differences in chronic disease and multimorbidity prevalence were observed across gender, age, education level, and marital status(all P<0. 05). Hypertension had the highest prevalence and comorbidity rate. The most common multimorbidity combination was arthritis or rheumatism+gastric diseases or digestive system diseases [2. 97%(568/19 128)]. Chronic disease prevalence across provinces ranged from 68. 2%(Guangdong) to 87. 8%(Heilongjiang), while multimorbidity prevalence ranged from 50. 3%(Fujian) to 72. 9%(Inner Mongolia Autonomous Region). Conclusions The prevalence of chronic diseases and multimorbidities among middle-aged and older adults in China remains high. Chronic disease management programs must prioritize preventing and managing hypertension, arthritis or rheumatism, and gastric diseases or digestive system diseases.
A study on the efficacy of traditional Chinese medicine auricular acupressure combined with abdominal rotation exercises in treating constipation in patients with Parkinson's disease after deep brain stimulation surgery
LIU Xiaochen;ZHU Shanshan;CHANG Xiaojie;YANG Xuehui;ZHANG Jianxin;ZHANG Jianbin;Objective To explore the effects of traditional Chinese medicine auricular acupressure combined with abdominal rotation exercise on constipation in patients with Parkinson's disease(PD) after deep brain stimulation(DBS) surgery. Methods A total of 102 PD patients who underwent DBS in the Department of Neurosurgery of Shandong Provincial Third Hospital Affiliated to Shandong University and were discharged for home or community rehabilitation from March 2024 to December 2024 were selected as the research subjects. They were randomly divided into the control group and the observation group by random number table method, with 51 cases in each group. The control group was given routine education, while the observation group was treated with traditional Chinese medicine auricular acupressure combined with abdominal rotation exercise on the basis of the control group. The colonic transit test, constipation severity score scale(CSS), and simple 8-item Parkinson's disease questionnaire(PDQ-8) were used to compare the colonic motility function, constipation symptoms, efficacy, and quality of life before and after treatment in the two groups. The levels of inflammatory factors C-reactive protein(CRP), interleukin-6(IL-6), and procalcitonin(PCT) before and after treatment were compared between the two groups. Results After treatment, the colonic transit test scores, CSS scores, PDQ-8 scores, and serum CRP and IL-6 levels in the observation group were lower than those in the control group, and the effective rate of constipation treatment was higher than that in the control group(all P < 0. 05). Conclusion Traditional Chinese medicine auricular acupressure combined with abdominal rotation exercise can enhance colonic motility function in PD patients after DBS, alleviate the severity of constipation, improve local intestinal inflammatory response, and improve the quality of life of patients.
