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Geriatrics Research
CN: 37-1522/R
ISSN: 2096-9058
Governed by: Health Commission of Shandong Province
Sponsored by: Shandong Provincial Hospital Affiliated to Shandong First Medical University
Editor-in-Chief: SUN Zhijian
Deputy Editor-in-Chief: WANG Jianchun
Founded in 2020, bimonthly.
Indexed by: CNKI, Wanfang, Weipu, Chaoxing, CBM.
Latent profile analysis of anxiety symptoms in older adults and its association with behavioral lifestyle
JIDA Wuniu;REN Zheng;LI Yujie;Objective To understand the latent classes of anxiety symptoms in older adults and to explore their associations with behavioral lifestyle. Methods Based on the Chinese Longitudinal Healthy Longevity Survey(CLHLS) data in 2018, a total of 10 900 older adults aged 60 and above were surveyed by using the General Information Questionnaire, the Behavioral Lifestyle Questionnaire and the Generalized Anxiety Disorder Scale. Latent profile analysis was used to identify the anxiety symptoms of older adults, and the relationship between different classes of anxiety symptoms and behavioral lifestyle was explored by multinomial logistic regression analysis. Results Anxiety symptoms of older adults were classified as low-level anxiety symptoms group(72. 97%), medium-level anxiety symptoms group(17. 54%), and highlevel anxiety symptoms group(9. 49%). The regression analysis showed that compared to older adults with low-level anxiety symptoms, those who slept ≤6 h/d were more likely to have medium-level anxiety symptoms(OR=1. 529, 95% CI: 1. 356-1. 723, P<0. 001), whereas those who drank alcohol regularly were at lower risk of medium-level anxiety symptoms(OR=0. 806, 95% CI: 0. 682-0. 953, P=0. 012). Those who slept ≤6 h/d(OR=2. 281, 95% CI: 1. 934-2. 691, P<0. 001), with low dietary diversity(OR=1. 452, 95% CI: 1. 139-1. 851, P=0. 003), and non-participants in leisure activities(OR=1. 321, 95% CI: 1. 079-1. 618, P=0. 007) were more likely to have high-level anxiety symptoms. Conclusions The anxiety symptoms of older adults have obvious classification characteristics and are closely related to behavioral lifestyle. Timely and effective intervention measures should be formulated for different categories to improve the anxiety symptoms of older adults.
Meta-analysis of the clinical efficacy and safety of moxibustion at the shenque acupoint for the treatment of functional constipation
QIU Hangyan;XU Qingyuan;LI Xuwen;MA Huitong;SHEN Yuxin;CHEN Hui;Objective To systematically evaluate the clinical efficacy and safety of moxibustion at the shenque acupoint in the treatment of functional constipation. Methods Computer searches were conducted in CNKI, Wanfang, VIP, China Biology Medicine disc, Web of Science, PubMed, Cochrane Library, and Embase for randomized controlled trials on moxibustion at the shenque acupoint for the treatment of functional constipation. The search period spanned from the inception of the databases to March 31, 2025. Two researchers independently performed literature screening, data extraction, and risk of bias assessment according to the inclusion and exclusion criteria. Meta-analysis was conducted using RevMan5. 4 software, and evidence quality was evaluated using GRADE. Results A total of 11 RCTs were included, with a total sample size of 988 cases, all in Chinese literature. Meta-analysis results showed that, compared with the control group, moxibustion on the shenque acupoint for functional constipation could improve the total effective rate(RR=1. 21, 95% CI: 1. 15-1. 27, P<0. 01), improve stool characteristics(MD=-1. 27, 95% CI:-1. 47--1. 07, P<0. 01), enhance quality of life(MD=-8. 20, 95% CI:-13. 59--2. 81, P<0. 01), reduce traditional Chinese medicine syndrome scores(SMD=-0. 94, 95% CI:-1. 32--0. 56, P<0. 01) and recurrence rate(RR=0. 57, 95% CI: 0. 43-0. 75, P<0. 01); regarding the incidence of adverse reactions, there was no statistically significant difference between the two groups(RR=0. 59, 95% CI: 0. 32-1. 09, P=0. 09). The results of the GRADE evidence level assessment indicated that the overall effective rate was of moderate quality evidence, the fecal consistency score and incidence of adverse reactions were of low quality evidence, and the scores for traditional Chinese medicine syndromes, quality of life, and relapse rate were of very low quality evidence. Conclusions Moxibustion at the shenque acupoint has a good therapeutic effect in treating functional constipation, which can improve constipation-related symptoms, and is safe and reliable. However, the quality of existing evidence is limited, and more high-quality research is needed for verification.
Influencing factors and construction of predictive model of preoperative frailty in elderly patients with prostate cancer
ZHANG Xumiao;HUA Hongxia;REN Guoqin;Objective To investigate the variables affecting preoperative frailty in elderly patients with prostate cancer and establish a risk prediction model. Methods A convenience sampling method was used to select 372 elderly patients with prostate cancer who had scheduled surgery in the Department of Urology, Jiangnan University Medical Center between September 2023 and September 2024 as the research subjects. The patients were evaluated using the general information survey, geriatric 8 frailty assessment, barthel index, athens insomnia scale, geriatric depression scale-15, social support rating scale(SSRS), and international prostate symptom score(IPSS). Binary logistic regression was used to explore the influencing factors of preoperative frailty in elderly patients with prostate cancer, and a predictive model was constructed accordingly. The Hosmer-Lemeshow test and receiver operating characteristic(ROC) curve analysis were used to evaluate the model's goodness-of-fit and predictive ability. Results A total of 372 elderly patients with prostate cancer were included in the analysis, with a preoperative frailty incidence of 44. 09%. According to binary logistic regression analysis, smoking history(OR=2. 303, 95% CI: 1. 048-4. 744), falls within the past year(OR=3. 761, 95% CI: 1. 326-10. 661), tumor stage(OR=14. 158, 95% CI: 5. 908-33. 941), insomnia(OR=2. 643, 95% CI: 1. 734-4. 028), and social support level(OR=0. 820, 95% CI: 0. 769-0. 875) were influencing factors of preoperative frailty in elderly patients with prostate cancer(all P<0. 05). The Hosmer-Lemeshow test showed χ2=10. 527, P=0. 230; the area under the ROC curve was 0. 885(95% CI: 0. 851-0. 919), with a maximum Youden index of 0. 652, a specificity of 0. 777, and a sensitivity of 0. 875, indicating good model performance. Conclusions Smoking history, falls within the past year, tumor stage, insomnia, and social support level are influencing factors of preoperative frailty in elderly patients with prostate cancer. The risk prediction model constructed based on these factors has a good fitting effect and excellent predictive performance, which is of reference value for clinical application and promotion.
Construction of a mortality risk prediction model for hospitalized patients with lower respiratory tract infection caused by ESBLs-producing Klebsiella pneumoniae
WANG Qiuxin;HE Huijie;NIU Haiying;ZHANG Run;WANG Cuifeng;Objective Construct a mortality risk prediction model for hospitalized patients with lower respiratory tract infections caused by extended-spectrum β-lactamase(ESBLs)-producing Klebsiella pneumoniae(ESBLs-KP), and conduct validation. Methods A total of 228 hospitalized patients diagnosed with ESBLs-KP lower respiratory tract infection in the First Affilated Hospital of Baotou Medical College from May 2020 to May 2025 were retrospectively enrolled. General information, underlying diseases, laboratory indicators, invasive procedures, and drug use were collected. Patients were divided into survival and death groups according to prognosis at the time of discharge. Single-factor analysis, χ2 test, Fisher's exact probability method, and multivariate logistic regression analysis were performed to identify the factors for mortality. A nomogram prediction model was constructed based on the factors, and its discrimination, calibration, and clinical application value were evaluated using the receiver operating characteristic(ROC) curve, calibration curve, and decision curve analysis. Results Among the 228 patients with ESBLs-KP lower respiratory tract infection, 60 died. Multivariate logistic regression analysis showed that indwelling nasogastric tube, history of ICU treatment, use of cefoperazone/sulbactam sodium, and use of piperacillin/tazobactam were risk factors for mortality in patients with ESBLs-KP infection. A nomogram prediction model was established based on these four factors, and a higher total score indicated a higher risk of death. Model validation showed that the area under the ROC curve was 0. 811(95% CI: 0. 750-0. 872), indicating good predictive performance. The calibration curve fitted well with the ideal curve, and decision curve analysis showed that the model had favorable net benefit within a certain threshold probability range. Conclusions Indwelling nasogastric tube, history of ICU treatment, use of cefoperazone/sulbactam sodium, and use of piperacillin/tazobactam are risk factors for death in patients with ESBLs-KP lower respiratory tract infections. The nomogram mortality risk prediction model established based on these factors has good discrimination, calibration, and clinical application value, which may help clinicians identify high-risk patients early and implement timely infection control measures, invasive procedure management, and optimized antimicrobial therapy, thereby improving patient prognosis.
A systematic review of risk prediction model for vision-threatening diabetic retinopathy
JIN Guiyang;PEI Yao;FANG Xinyi;ZHANG Guijuan;Objective To systematically evaluate risk prediction models for vision-threatening diabetic retinopathy(VTDR). Methods Search for relevant literature in Chinese and English databases, including CNKI, VIP, Wanfang, China Biomedical Literature Database, CINAHL, PubMed, Embase, Web of Science, ProQuest, Ovid, and Cochrane Library, from the inception of each database up to December 2025. Researchers will screen the literature according to inclusion and exclusion criteria. Two researchers will independently extract data and assess quality using a predesigned data extraction form and bias risk assessment tool. Results A total of seven studies involving nine VTDR risk prediction models were included, with sample sizes ranging from 416 to 40 334 participants and outcome events from 50 to 6 187. The area under the receiver operating characteristic curve ranged from 0. 69 to 0. 96. Seven models reported calibration performance, and seven underwent external validation. The top five most frequently reported predictors across models were age, duration of diabetes, glycated hemoglobin, blood pressure, and body mass index. The predictive applicability of the existing models was generally good, but the overall risk of bias was relatively high, mainly due to flaws in research design, improper handling of missing data, and insufficient validation. Conclusions Current VTDR risk prediction models are still in developmental stages, with significant differences in predictors across studies, and further optimization and improvement are still needed. Future studies should require more prospective, multicenter, and large-sample designs, and verify their applicability and feasibility in clinical practice.
