nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg searchdiv qikanlogo popupnotification paper
2025 02 v.6 18-23
Application of comprehensive geriatric assessment in identifying risk and protective factors for sarcopenia in individuals aged ≥90 years
Email: erinzt@sina.com;
DOI:
English author unit:

Department of General Medicine, Affiliated Jiangyin Hospital of Nantong University;

Abstract:

Objective To explore the application of comprehensive geriatric assessment(CGA) in identifying risk and protective factors for sarcopenia among individuals aged ≥90 years. Methods A total of 190 ultra-elderly patients aged ≥90 years who were treated in Jiangyin People's Hospital Medical Group and Jiangyin Community Health Service Center from January 2018 to August 2022 were enrolled. CGA was conducted for comprehensive evaluation, and logistic regression analysis was performed to identify sarcopenia-related factors. Results Among 190 participants, 118(62. 11%) were diagnosed with sarcopenia. Risk factors included polypharmacy(OR=1. 303, 95% CI: 1. 100-1. 543), sleep disorders(OR=2. 974, 95% CI: 1. 307-6. 770), smoking history(OR=2. 511, 95% CI: 1. 067-5. 910), depression(OR=4. 157, 95% CI: 1. 776-9. 730), and nutritional risk(OR=2. 402, 95% CI: 1. 071-5. 389)(all P<0. 05). Protective factors included being married(OR=0. 345, 95% CI: 0. 139-0. 858), BMI(OR=0. 702, 95% CI: 0. 592-0. 833), elevated uric acid(OR=0. 996, 95% CI: 0. 993-1. 000), and total cholesterol(OR=0. 535, 95% CI: 0. 314-0. 912)(all P<0. 05). Conclusions The prevalence of sarcopenia in individuals aged ≥90 years is significantly higher than in the general elderly population. CGA highlights modifiable factors such as polypharmacy, smoking, marital status, metabolic indicators(BMI, cholesterol, uric acid, nutritional risk), and psychosocial factors(depression, sleep disorders), offering evidence for multidimensional interventions.

KeyWords: sarcopenia;comprehensive geriatric assessment;oldest-old;aged
References

[1] WANG L, TANG Y, ROSHANMEHR F, et al. The health status transition and medical expenditure evaluation of elderly population in China[J]. Int J Environ Res Public Health, 2021,18(13):6907.

[2] LIU Y, ZHANG C W, ZHAO X D. Long-term survival of femoral neck fracture patients aged over ninety years:arthroplasty compared with nonoperative treatment[J]. BMC Musculoskelet Disord, 2020,21(1):217.

[3] BAI R, LIU Y, ZHANG L,et al. Projections of future life expectancy in China up to 2035:a modelling study[J]. Lancet Public Health, 2023,8(12):e915-e922.

[4] CHEN Z, LI W Y, HO M, et al. The prevalence of sarcopenia in Chinese older adults:meta-analysis and meta-regression[J]. Nutrients, 2021,13(5):1441.

[5] CHEN L K, WOO J, ASSANTACHAI P, et al. Asian working group for sarcopenia:2019 consensus update on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc, 2020,21(3):300-307. e2.

[6]闫妍,王育琴,沈芊,等.中国老年人潜在不适当用药目录的研制[J].药物不良反应杂志,2015,17(1):19-26.

[7] YANG Y, MENG Y, DONG P. Health, security and participation:a structural relationship modeling among the three pillars of active ageing in China[J]. Int J Environ Res Public Health,2020,17(19):7255.

[8]孙超,侯莉明,简伟明,等.我国60岁以上老年人群肌少症患病率及相关因素调查[J].中华老年医学杂志,2021,40(8):981-986.

[9] LUO Q, CHENG D, HUANG C, et al. Improvement of colonic immune function with soy isoflavones in high-fat diet-induced obese rats[J]. Molecules, 2019,24(6):1139.

[10] GAO L, JIANG J, YANG M, et al. Prevalence of sarcopenia and associated factors in chinese community-dwelling elderly:comparison between rural and urban areas[J]. J Am Med Dir Assoc,2015,16(11):1003. e1-1003.

[11]王楠,魏雅楠,刘杰,等.住院老年慢性病患者肌少症的相关影响因素分析[J].中国全科医学,2020,23(5):611-616.

[12] GAO Q, HU K, YAN C, et al. Associated factors of sarcopenia in community-dwelling older adults:a systematic review and meta-analysis[J]. Nutrients, 2021,13(12):4291.

[13] DAI X, WANG L, REN Y. The effects of China's targeted poverty alleviation policy on the health and health equity of rural poor residents:evidence from shaanxi province[J]. Healthcare(Basel), 2020,8(3):256.

[14] BAUMGARTNER R N, WAYNE S J, WATERS D L, et al. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly[J]. Obes Res, 2004,12(12):1995-2004.

[15] XU Z R, ZHANG Q, CHEN L F, et al. Characteristics of hyperuricemia in older adults in China and possible associations with sarcopenia[J]. Aging Med(Milton), 2018,1(1):23-34.

[16] KUCIEL-LEWANDOWSKA J, KASPERCZAK M, BOGUT B, et al. The impact of health resort treatment on the nonenzymatic endogenous antioxidant system[J]. Oxid Med Cell Longev, 2020,2020:8423105.

[17]刘璐,毛拥军,冯媛媛,等.老年住院病人尿酸水平与营养状态的相关性[J].青岛大学学报(医学版),2020,56(3):297-300.

[18] JAHAN S, AZAD T, AYUB A, et al. Ameliorating potency of chenopodium album linn. and vitamin c against mercuric chloride-induced oxidative stress in testes of sprague dawley rats[J].Environ Health Prev Med, 2019,24(1):62.

[19] DAVIDYAN A, PATHAK S, BAAR K, et al. Maintenance of muscle mass in adult male mice is independent of testosterone[J]. PLoS One, 2021,16(3):e0240278.

[20]南亚昀,彭琳琳,高叙凡,等.慢性阻塞性肺疾病合并肌少症[J].中国实用内科杂志,2022,42(8):626-630.

[21] SGANGA F, VETRANO D L, VOLPATO S, et al. Physical performance measures and polypharmacy among hospitalized older adults:results from the CRIME study[J]. J Nutr Health Aging,2014,18(6):616-621.

[22] TAN X, TITOVA O E, LINDBERG E, et al. Association between self-reported sleep duration and body composition in middle-aged and older adults[J]. J Clin Sleep Med, 2019,15(3):431-435.

[23]赵子龙,李维辛,邓玉洁,等.睡眠障碍与肌少症相关性的研究进展[J].宁夏医科大学学报,2021,43(8):865-869.

[24] WU H, YU B, MENG G, et al. Both muscle mass and muscle strength are inversely associated with depressive symptoms in an elderly Chinese population[J]. Int J Geriatr Psychiatry, 2017,32(7):769-778.

[25] HAI S, CAO L, WANG H, et al. Association between sarcopenia and nutritional status and physical activity among communitydwelling Chinese adults aged 60 years and older[J]. Geriatr Gerontol Int, 2017,17(11):1959-1966.

[26] BEAUDART C, SANCHEZ-RODRIGUEZ D, LOCQUET M, et al. Malnutrition as a strong predictor of the onset of sarcopenia[J]. Nutrients, 2019,11(12):2883.

[27] YUKSEL O H, AKAN S, URKMEZ A, et al. Preoperative glasgow prognostic score as a predictor of primary bladder cancer recurrence[J]. Mol Clin Oncol, 2016,5(1):201-206.

Basic Information:

DOI:

China Classification Code:R685

Citation Information:

[1]张恬,沙江明,江黎明等.老年综合评估在≥90岁超高龄人群肌少症影响因素分析中的应用[J].老年医学研究,2025,6(02):18-23.

Fund Information:

江苏省卫生健康委员会临床适宜技术推广应用项目(LSD2022007,老年综合评估技术在基层医疗机构中的推广应用);江苏省卫生健康委员会临床技术应用研究项目(LD2022005,老年医学临床技术应用研究项目单位)

quote

GB/T 7714-2015
MLA
APA
Search Advanced Search